Clinical trials in allied medical fields: A cross-sectional analysis of World Health Organization International Clinical Trial Registry Platform
Identifieur interne : 001287 ( Main/Exploration ); précédent : 001286; suivant : 001288Clinical trials in allied medical fields: A cross-sectional analysis of World Health Organization International Clinical Trial Registry Platform
Auteurs : S. Kannan [Fidji] ; S. Gowri [Fidji]Source :
- Journal of Ayurveda and Integrative Medicine [ 0975-9476 ] ; 2016.
Abstract
Clinical trials are mandatory for evidence-based practice. Hardly, any data are available regarding the number of clinical trials and their methodological quality that are conducted in allied fields of medicine.
The present study was envisaged to assess methodological quality of trials in allied medical fields.
Registered clinical trials in World Health Organization International Clinical Trials Registry Platform (
A total of 276 clinical trials were registered majority of which have been proposed to be conducted in the field of oncology and psychiatry. Most of the clinical trials were done in single centers (87.75%), and almost all the clinical trials were investigator-initiated with pharmaceutical company sponsored studies contributing to a maximum extent of 24.5%. A large majority of the study designs were interventional where almost 85% of the studies were randomized controlled trials. However, an appropriate method of randomization was mentioned only in 27.4%, and the rate of allocation concealment was found to be just 5.5%. Only 1–2% of the completed studies were published, and the average rate of retrospective registration was found to be 23.6% in various fields.
The number of clinical trials done in allied fields of medicine other than the allopathic system has lowered down, and furthermore focus is required regarding the methodological quality of these trials and more support from various organizations.
Url:
DOI: 10.1016/j.jaim.2015.09.003
PubMed: 27297510
PubMed Central: 4910572
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 004020
- to stream Pmc, to step Curation: 004019
- to stream Pmc, to step Checkpoint: 000B16
- to stream Ncbi, to step Merge: 008423
- to stream Ncbi, to step Curation: 008423
- to stream Ncbi, to step Checkpoint: 008423
- to stream Main, to step Merge: 001289
- to stream Main, to step Curation: 001287
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Clinical trials in allied medical fields: A cross-sectional analysis of World Health Organization International Clinical Trial Registry Platform</title><author><name sortKey="Kannan, S" sort="Kannan, S" uniqKey="Kannan S" first="S." last="Kannan">S. Kannan</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Health Sciences, Fiji National University, Suva, Fiji</nlm:aff><country xml:lang="fr">Fidji</country><wicri:regionArea>Department of Health Sciences, Fiji National University, Suva</wicri:regionArea><wicri:noRegion>Suva</wicri:noRegion></affiliation></author><author><name sortKey="Gowri, S" sort="Gowri, S" uniqKey="Gowri S" first="S." last="Gowri">S. Gowri</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Oral Health, Fiji National University, Suva, Fiji</nlm:aff><country xml:lang="fr">Fidji</country><wicri:regionArea>Department of Oral Health, Fiji National University, Suva</wicri:regionArea><wicri:noRegion>Suva</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">27297510</idno><idno type="pmc">4910572</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4910572</idno><idno type="RBID">PMC:4910572</idno><idno type="doi">10.1016/j.jaim.2015.09.003</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">004020</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">004020</idno><idno type="wicri:Area/Pmc/Curation">004019</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">004019</idno><idno type="wicri:Area/Pmc/Checkpoint">000B16</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000B16</idno><idno type="wicri:Area/Ncbi/Merge">008423</idno><idno type="wicri:Area/Ncbi/Curation">008423</idno><idno type="wicri:Area/Ncbi/Checkpoint">008423</idno><idno type="wicri:doubleKey">0975-9476:2016:Kannan S:clinical:trials:in</idno><idno type="wicri:Area/Main/Merge">001289</idno><idno type="wicri:Area/Main/Curation">001287</idno><idno type="wicri:Area/Main/Exploration">001287</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Clinical trials in allied medical fields: A cross-sectional analysis of World Health Organization International Clinical Trial Registry Platform</title><author><name sortKey="Kannan, S" sort="Kannan, S" uniqKey="Kannan S" first="S." last="Kannan">S. Kannan</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Health Sciences, Fiji National University, Suva, Fiji</nlm:aff><country xml:lang="fr">Fidji</country><wicri:regionArea>Department of Health Sciences, Fiji National University, Suva</wicri:regionArea><wicri:noRegion>Suva</wicri:noRegion></affiliation></author><author><name sortKey="Gowri, S" sort="Gowri, S" uniqKey="Gowri S" first="S." last="Gowri">S. Gowri</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Oral Health, Fiji National University, Suva, Fiji</nlm:aff><country xml:lang="fr">Fidji</country><wicri:regionArea>Department of Oral Health, Fiji National University, Suva</wicri:regionArea><wicri:noRegion>Suva</wicri:noRegion></affiliation></author></analytic><series><title level="j">Journal of Ayurveda and Integrative Medicine</title><idno type="ISSN">0975-9476</idno><idno type="eISSN">0976-2809</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Clinical trials are mandatory for evidence-based practice. Hardly, any data are available regarding the number of clinical trials and their methodological quality that are conducted in allied fields of medicine.</p></sec><sec><title>Objective</title><p>The present study was envisaged to assess methodological quality of trials in allied medical fields.</p></sec><sec><title>Materials and Methods</title><p>Registered clinical trials in World Health Organization International Clinical Trials Registry Platform (<ext-link ext-link-type="uri" xlink:href="http://apps.who.int/trialsearch/AdvSearch.aspx" id="intref0010">http://apps.who.int/trialsearch/AdvSearch.aspx</ext-link>) in the following fields were extracted: Acupuncture; Ayurveda; biofeedback; complementary and alternate medicine; herbal; homeopathy; massage; naturopathy; Reiki; Siddha; Unani; and yoga. The eligible studies were assessed for the following key details: Type of sponsors; health condition in which the trial has been conducted; recruitment status; study design; if randomization was present, method of randomization and allocation concealment; single or multi-centric; retrospective or prospective registration; and publication status in case of completed studies.</p></sec><sec><title>Results</title><p>A total of 276 clinical trials were registered majority of which have been proposed to be conducted in the field of oncology and psychiatry. Most of the clinical trials were done in single centers (87.75%), and almost all the clinical trials were investigator-initiated with pharmaceutical company sponsored studies contributing to a maximum extent of 24.5%. A large majority of the study designs were interventional where almost 85% of the studies were randomized controlled trials. However, an appropriate method of randomization was mentioned only in 27.4%, and the rate of allocation concealment was found to be just 5.5%. Only 1–2% of the completed studies were published, and the average rate of retrospective registration was found to be 23.6% in various fields.</p></sec><sec><title>Conclusion</title><p>The number of clinical trials done in allied fields of medicine other than the allopathic system has lowered down, and furthermore focus is required regarding the methodological quality of these trials and more support from various organizations.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Titler, M G" uniqKey="Titler M">M.G. Titler</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Pasquali, S K" uniqKey="Pasquali S">S.K. Pasquali</name></author><author><name sortKey="Lam, W K" uniqKey="Lam W">W.K. Lam</name></author><author><name sortKey="Chiswell, K" uniqKey="Chiswell K">K. Chiswell</name></author><author><name sortKey="Kemper, A R" uniqKey="Kemper A">A.R. Kemper</name></author><author><name sortKey="Li, J S" uniqKey="Li J">J.S. Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Guo, S W" uniqKey="Guo S">S.W. Guo</name></author><author><name sortKey="Hummelshoj, L" uniqKey="Hummelshoj L">L. Hummelshoj</name></author><author><name sortKey="Olive, D L" uniqKey="Olive D">D.L. Olive</name></author><author><name sortKey="Bulun, S E" uniqKey="Bulun S">S.E. Bulun</name></author><author><name sortKey="D Hooghe, T M" uniqKey="D Hooghe T">T.M. D'Hooghe</name></author><author><name sortKey="Evers, J L" uniqKey="Evers J">J.L. Evers</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chiappelli, F" uniqKey="Chiappelli F">F. Chiappelli</name></author><author><name sortKey="Prolo, P" uniqKey="Prolo P">P. Prolo</name></author><author><name sortKey="Rosenblum, M" uniqKey="Rosenblum M">M. Rosenblum</name></author><author><name sortKey="Edgerton, M" uniqKey="Edgerton M">M. Edgerton</name></author><author><name sortKey="Cajulis, O S" uniqKey="Cajulis O">O.S. Cajulis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cairo, F" uniqKey="Cairo F">F. Cairo</name></author><author><name sortKey="Sanz, I" uniqKey="Sanz I">I. Sanz</name></author><author><name sortKey="Matesanz, P" uniqKey="Matesanz P">P. Matesanz</name></author><author><name sortKey="Nieri, M" uniqKey="Nieri M">M. Nieri</name></author><author><name sortKey="Pagliaro, U" uniqKey="Pagliaro U">U. Pagliaro</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kennedy, H L" uniqKey="Kennedy H">H.L. Kennedy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bellomo, R" uniqKey="Bellomo R">R. Bellomo</name></author><author><name sortKey="Bagshaw, S M" uniqKey="Bagshaw S">S.M. Bagshaw</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schulz, K F" uniqKey="Schulz K">K.F. Schulz</name></author><author><name sortKey="Grimes, D A" uniqKey="Grimes D">D.A. Grimes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="He, J" uniqKey="He J">J. He</name></author><author><name sortKey="Du, L" uniqKey="Du L">L. Du</name></author><author><name sortKey="Liu, G" uniqKey="Liu G">G. Liu</name></author><author><name sortKey="Fu, J" uniqKey="Fu J">J. Fu</name></author><author><name sortKey="He, X" uniqKey="He X">X. He</name></author><author><name sortKey="Yu, J" uniqKey="Yu J">J. Yu</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Jadad, A R" uniqKey="Jadad A">A.R. Jadad</name></author><author><name sortKey="Moore, R A" uniqKey="Moore R">R.A. Moore</name></author><author><name sortKey="Carroll, D" uniqKey="Carroll D">D. Carroll</name></author><author><name sortKey="Jenkinson, C" uniqKey="Jenkinson C">C. Jenkinson</name></author><author><name sortKey="Reynolds, D J" uniqKey="Reynolds D">D.J. Reynolds</name></author><author><name sortKey="Gavaghan, D J" uniqKey="Gavaghan D">D.J. Gavaghan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schulz, K F" uniqKey="Schulz K">K.F. Schulz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schulz, K F" uniqKey="Schulz K">K.F. Schulz</name></author><author><name sortKey="Chalmers, I" uniqKey="Chalmers I">I. Chalmers</name></author><author><name sortKey="Hayes, R J" uniqKey="Hayes R">R.J. Hayes</name></author><author><name sortKey="Altman, D G" uniqKey="Altman D">D.G. Altman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jones, C W" uniqKey="Jones C">C.W. Jones</name></author><author><name sortKey="Handler, L" uniqKey="Handler L">L. Handler</name></author><author><name sortKey="Crowell, K E" uniqKey="Crowell K">K.E. Crowell</name></author><author><name sortKey="Keil, L G" uniqKey="Keil L">L.G. Keil</name></author><author><name sortKey="Weaver, M A" uniqKey="Weaver M">M.A. Weaver</name></author><author><name sortKey="Platts Mills, T F" uniqKey="Platts Mills T">T.F. Platts-Mills</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ross, J S" uniqKey="Ross J">J.S. Ross</name></author><author><name sortKey="Mulvey, G K" uniqKey="Mulvey G">G.K. Mulvey</name></author><author><name sortKey="Hines, E M" uniqKey="Hines E">E.M. Hines</name></author><author><name sortKey="Nissen, S E" uniqKey="Nissen S">S.E. Nissen</name></author><author><name sortKey="Krumholz, H M" uniqKey="Krumholz H">H.M. Krumholz</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Fidji</li></country></list><tree><country name="Fidji"><noRegion><name sortKey="Kannan, S" sort="Kannan, S" uniqKey="Kannan S" first="S." last="Kannan">S. Kannan</name></noRegion><name sortKey="Gowri, S" sort="Gowri, S" uniqKey="Gowri S" first="S." last="Gowri">S. Gowri</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001287 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001287 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= LymphedemaV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:4910572
|texte= Clinical trials in allied medical fields: A cross-sectional analysis of World Health Organization International Clinical Trial Registry Platform
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:27297510" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a LymphedemaV1
| This area was generated with Dilib version V0.6.31. |  |